THE EVOLUTIONARY EPIDEMIOLOGY OF MULTILOCUS DRUG RESISTANCE
نویسندگان
چکیده
منابع مشابه
The evolutionary epidemiology of multilocus drug resistance.
The evolution of resistance to drugs is a major public health concern as it erodes the efficacy of our therapeutic arsenal against bacterial, viral, and fungal pathogens. Increasingly, it is recognized that the evolution of resistance involves genetic changes at more than one locus, both in cases where multiple changes are required to obtain high-level resistance, and where compensatory changes...
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Drug resistance is a long-standing economic, veterinary and human health concern in human and animal populations. Efficacy of prophylactic drug treatments targeting a particular pathogen is often short-lived, as drug-resistant pathogens evolve and reach high frequency in a treated population. Methods to combat drug resistance are usually costly, including use of multiple drugs that are applied ...
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The emergence of drug-resistant pathogens is often considered a canonical case of evolution by natural selection. Here we argue that the strength of selection can be a poor predictor of the rate of resistance emergence. It is possible for a resistant strain to be under negative selection and still emerge in an infection or spread in a population. Measuring the right parameters is a necessary fi...
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ژورنال
عنوان ژورنال: Evolution
سال: 2012
ISSN: 0014-3820
DOI: 10.1111/j.1558-5646.2011.01533.x